Arginine butyrate increases the cytotoxicity of DAB389IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rβ gene
RH Shao, X Tian, G Gorgun, AG Urbano, FM Foss - Leukemia research, 2002 - Elsevier
DAB389IL-2 (ONTAK) is a fusion protein consisting of the ADP-ribosyltransferase and
membrane translocating domains of native diphtheria toxin and the full-length sequence for
interleukin-2 (IL-2) gene. In vitro data demonstrates that DAB389IL-2 is cytotoxic to cells
expressing the high affinity IL-2 receptor (IL-2R). In Phases I and II clinical trials of patients
whose tumor cells express a component of the IL-2R, the response rates were 18% for B-cell
non-Hodgkin lymphoma (NHL) and 30% for cutaneous T-cell lymphoma (CTCL). In this …
membrane translocating domains of native diphtheria toxin and the full-length sequence for
interleukin-2 (IL-2) gene. In vitro data demonstrates that DAB389IL-2 is cytotoxic to cells
expressing the high affinity IL-2 receptor (IL-2R). In Phases I and II clinical trials of patients
whose tumor cells express a component of the IL-2R, the response rates were 18% for B-cell
non-Hodgkin lymphoma (NHL) and 30% for cutaneous T-cell lymphoma (CTCL). In this …