Granulocyte-macrophage colony stimulating factor: an adjuvant for cancer vaccines

DZ Chang, W Lomazow, C Joy Somberg, R Stan… - …, 2004 - Taylor & Francis
DZ Chang, W Lomazow, C Joy Somberg, R Stan, MA Perales
Hematology, 2004Taylor & Francis
Granulocyte-macrophage colony stimulating factor (GM-CSF) enhances immune responses
by inducing the proliferation, maturation, and migration of dendritic cells, and the expansion
and differentiation of B and T lymphocytes. There is significant data in pre-clinical animal
models demonstrating the adjuvant effects of GM-CSF in a variety of cancer vaccine
approaches, including cellular vaccines, viral vaccines, peptide and protein vaccines, and
DNA vaccines. GM-CSF is an attractive vaccine adjuvant because of its immune modulation …
Abstract
Granulocyte-macrophage colony stimulating factor (GM-CSF) enhances immune responses by inducing the proliferation, maturation, and migration of dendritic cells, and the expansion and differentiation of B and T lymphocytes. There is significant data in pre-clinical animal models demonstrating the adjuvant effects of GM-CSF in a variety of cancer vaccine approaches, including cellular vaccines, viral vaccines, peptide and protein vaccines, and DNA vaccines. GM-CSF is an attractive vaccine adjuvant because of its immune modulation effects and low toxicity profile. The results in animal models have been confirmed in pilot clinical trials and several clinical trials are currently ongoing.
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