Inflamed joints of patients with rheumatoid arthritis contain T cells that display in vitro proliferation to antigens present in autologous synovial fluid functional analysis …
L Struijk, A Leow, MR Daha, PC van den Elsen… - Human immunology, 1994 - Elsevier
The immunopathology of inflamed joints in patients with RA is thought to result from an
antigen-driven T-cell response. The antigen (s) responsible for the activation of synovial T
cells, however, are as yet unidentified. In this study, we tested SF as a potential source of
(auto) antigen (s). Five of 15 IL-2-expanded T-cell lines generated from SF cells of RA
patients displayed a proliferative response to autologous SF. Five CD4+ CD8-αβ TCR+ SF-
reactive T-cell clones obtained from responder T-cell lines were studied in more detail …
antigen-driven T-cell response. The antigen (s) responsible for the activation of synovial T
cells, however, are as yet unidentified. In this study, we tested SF as a potential source of
(auto) antigen (s). Five of 15 IL-2-expanded T-cell lines generated from SF cells of RA
patients displayed a proliferative response to autologous SF. Five CD4+ CD8-αβ TCR+ SF-
reactive T-cell clones obtained from responder T-cell lines were studied in more detail …