[HTML][HTML] Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins
GRS Budinger, M Tso, DS McClintock, DA Dean… - Journal of biological …, 2002 - ASBMB
Exposure of animals to hyperoxia results in lung injury that is characterized by apoptosis
and necrosis of the alveolar epithelium and endothelium. The mechanism by which
hyperoxia results in cell death, however, remains unclear. We sought to test the hypothesis
that exposure to hyperoxia causes mitochondria-dependent apoptosis that requires the
generation of reactive oxygen species from mitochondrial electron transport. Rat1a cells
exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c …
and necrosis of the alveolar epithelium and endothelium. The mechanism by which
hyperoxia results in cell death, however, remains unclear. We sought to test the hypothesis
that exposure to hyperoxia causes mitochondria-dependent apoptosis that requires the
generation of reactive oxygen species from mitochondrial electron transport. Rat1a cells
exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c …