[HTML][HTML] A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor
PJ Duriez, F Wong, K Dorovini-Zis, R Shahidi… - Journal of Biological …, 2000 - ASBMB
Tumor necrosis factor (TNF) does not cause endothelial apoptosis unless the expression of
cytoprotective genes is blocked. We have previously demonstrated that one of the TNF-
inducible cytoprotective genes is the Bcl-2 family member, A1. A1 is induced by the action of
the transcription factor, NFκB, in response to inflammatory mediators. In this report we
demonstrate that, as with other cell types, inhibition of NFκB initiates microvascular
endothelial apoptosis in response to TNF. A1 is able to inhibit this apoptosis over 24 h. We …
cytoprotective genes is blocked. We have previously demonstrated that one of the TNF-
inducible cytoprotective genes is the Bcl-2 family member, A1. A1 is induced by the action of
the transcription factor, NFκB, in response to inflammatory mediators. In this report we
demonstrate that, as with other cell types, inhibition of NFκB initiates microvascular
endothelial apoptosis in response to TNF. A1 is able to inhibit this apoptosis over 24 h. We …