[HTML][HTML] Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway
X Wang, SW Ryter, C Dai, ZL Tang, SC Watkins… - Journal of biological …, 2003 - ASBMB
Human epithelial (A549) cells exposed to hyperoxia die by cellular necrosis. In the current
study, we demonstrated the involvement of apoptogenic factors in epithelial cell necrosis in
response to hyperoxia, including the formation of the Fas-related death-inducing signaling
complex and initiation of mitochondria-dependent apoptotic pathways. We showed
increased activation of both Bid and Bax in A549 cells subjected to hyperoxia. Bax activation
involved a Bid-assisted conformational change. We discovered that the response to …
study, we demonstrated the involvement of apoptogenic factors in epithelial cell necrosis in
response to hyperoxia, including the formation of the Fas-related death-inducing signaling
complex and initiation of mitochondria-dependent apoptotic pathways. We showed
increased activation of both Bid and Bax in A549 cells subjected to hyperoxia. Bax activation
involved a Bid-assisted conformational change. We discovered that the response to …