[HTML][HTML] Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment
Stearoyl-CoA desaturase (SCD) is a microsomal enzyme involved in the biosynthesis of
oleate and palmitoleate. Mice with a targeted disruption of the SCD1 isoform (SCD1−/−)
exhibit reduced adiposity and increased energy expenditure. To address whether the
energy expenditure is attributable to increased thermogenesis, we investigated the effect of
SCD1 deficiency on basal and cold-induced thermogenesis. SCD1−/− mice have increased
expression of uncoupling proteins in brown adipose tissue (BAT) relative to controls. The β3 …
oleate and palmitoleate. Mice with a targeted disruption of the SCD1 isoform (SCD1−/−)
exhibit reduced adiposity and increased energy expenditure. To address whether the
energy expenditure is attributable to increased thermogenesis, we investigated the effect of
SCD1 deficiency on basal and cold-induced thermogenesis. SCD1−/− mice have increased
expression of uncoupling proteins in brown adipose tissue (BAT) relative to controls. The β3 …