The hypothalamic–pituitary–adrenal axis and immune-mediated inflammation

GP Chrousos - New England Journal of Medicine, 1995 - Mass Medical Soc
New England Journal of Medicine, 1995Mass Medical Soc
Celsus described four of the five cardinal signs of inflammation 2000 years ago, and
Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye
note that in rats exposed to stressors, the adrenal glands were enlarged, and the thymus
and lymph nodes shrunken. 1–3 Cortisone, the active principle of the adrenal glands, was
isolated by Kendall and Reichstein in the late 1940s and shown to suppress immune
organs. These scientists, along with Hench, received the Nobel Prize in Physiology and …
Celsus described four of the five cardinal signs of inflammation 2000 years ago, and Eustachio discovered the adrenal glands almost 500 years ago, but not until 1936 did Selye note that in rats exposed to stressors, the adrenal glands were enlarged, and the thymus and lymph nodes shrunken.13 Cortisone, the active principle of the adrenal glands, was isolated by Kendall and Reichstein in the late 1940s and shown to suppress immune organs. These scientists, along with Hench, received the Nobel Prize in Physiology and Medicine, after Hench and colleagues showed that cortisone could ameliorate rheumatoid arthritis.4,5
In recent . . .
The New England Journal Of Medicine