The common forms of cardiovascular disease (CVD) have a complex etiology, involving
multiple genetic influences and important environmental interactions. Because of this
complexity, it has proved difficult to apply the positional cloning approaches that have
revolutionized understanding of Mendelian (single-gene) disorders; and the understanding
of the genetics of CVD and its underlying cause, atherosclerosis, remains poor. This review,
organized into 10 broad questions, summarizes the understanding of the genetics of …