[HTML][HTML] ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB
Human immunodeficiency virus type 1 (HIV-1) can establish latent infection following
provirus integration into the host genome. NF-κB plays a critical role in activation of HIV-1
gene expression by cytokines and other stimuli, but the signal transduction pathways that
regulate the switch from latent to productive infection have not been defined. Here, we show
that ERK1/ERK2 mitogen-activated protein kinase (MAPK) plays a central role in linking
signals at the cell surface to activation of HIV-1 gene expression in latently infected cells …
provirus integration into the host genome. NF-κB plays a critical role in activation of HIV-1
gene expression by cytokines and other stimuli, but the signal transduction pathways that
regulate the switch from latent to productive infection have not been defined. Here, we show
that ERK1/ERK2 mitogen-activated protein kinase (MAPK) plays a central role in linking
signals at the cell surface to activation of HIV-1 gene expression in latently infected cells …