IL-13 receptors and signaling pathways: an evolving web
GKK Hershey - Journal of Allergy and Clinical Immunology, 2003 - Elsevier
Continuing Medical Education examination IL-13 is an immunoregulatory cytokine secreted
predominantly by activated TH2 cells. Over the past several years, it has become evident
that IL-13 is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many
functional properties with IL-4, stemming from the fact that they share a common receptor
subunit, the α subunit of the IL-4 receptor (IL-4Rα). Characterization of IL-13–deficient mice,
IL-4–deficient mice, and IL-4 receptor α–deficient (IL-4Rα−/−) mice have demonstrated …
predominantly by activated TH2 cells. Over the past several years, it has become evident
that IL-13 is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many
functional properties with IL-4, stemming from the fact that they share a common receptor
subunit, the α subunit of the IL-4 receptor (IL-4Rα). Characterization of IL-13–deficient mice,
IL-4–deficient mice, and IL-4 receptor α–deficient (IL-4Rα−/−) mice have demonstrated …