[PDF][PDF] RETRACTED: DNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA
WM Chu, X Gong, ZW Li, K Takabayashi, HH Ouyang… - Cell, 2000 - cell.com
WM Chu, X Gong, ZW Li, K Takabayashi, HH Ouyang, Y Chen, A Lois, DJ Chen, GC Li…
Cell, 2000•cell.comDNA-PKcs Is Required for Activation of Innate Immunity by Immunostimulatory DNA Page 1 Cell,
Vol. 103, 909–918, December 8, 2000, Copyright ©2000 by Cell Press DNA-PKcs Is Required for
Activation of Innate Immunity by Immunostimulatory DNA inactive ODNs suggested that
palindromic hexamers, each of which contains nonmethylated CpG dinucleotides, are
responsible for this immune activation (Ya- Wen-Ming Chu,* Xing Gong,* Zhi-Wei Li,† Kenji
Takabayashi,* Hong-Hai Ouyang,‡ Yi Chen,† Augusto Lois,* David J. Chen,§ Gloria C. Li,‡ …
Vol. 103, 909–918, December 8, 2000, Copyright ©2000 by Cell Press DNA-PKcs Is Required for
Activation of Innate Immunity by Immunostimulatory DNA inactive ODNs suggested that
palindromic hexamers, each of which contains nonmethylated CpG dinucleotides, are
responsible for this immune activation (Ya- Wen-Ming Chu,* Xing Gong,* Zhi-Wei Li,† Kenji
Takabayashi,* Hong-Hai Ouyang,‡ Yi Chen,† Augusto Lois,* David J. Chen,§ Gloria C. Li,‡ …
Summary sine in the CpG dinucleotide (5-methylCpG) reduces this immunostimulatory activity (Krieg et al., 1995). This phe-
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