Ras‐related genes in Dictyostelium discoideum

SM Robbins, M Khosla, R Thiery… - Developmental …, 1991 - Wiley Online Library
SM Robbins, M Khosla, R Thiery, G Weeks, GB Spiegelman
Developmental Genetics, 1991Wiley Online Library
Dicfyostelium discoideum, like other eukaryotes, has been shown to express several ras‐
related genes. Two gene products, Ddras and DdrasG, are highly conserved relative to the
human ras proteins. Ddras is expressed at the pseudoplasmodial stage of development,
whereas DdrasG is expressed in vegetative cells and during early development. In addition,
Dicfyostelium possesses three ras‐related genes, SAS1, SAS2 and Ddrap1, whose gene
products are only partially conserved relative to those of the ras genes. The expression of …
Abstract
Dicfyostelium discoideum, like other eukaryotes, has been shown to express several ras‐related genes. Two gene products, Ddras and DdrasG, are highly conserved relative to the human ras proteins. Ddras is expressed at the pseudoplasmodial stage of development, whereas DdrasG is expressed in vegetative cells and during early development. In addition, Dicfyostelium possesses three ras‐related genes, SAS1, SAS2 and Ddrap1, whose gene products are only partially conserved relative to those of the ras genes. The expression of these three genes is also developmentally regulated.
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