[HTML][HTML] Parathyroid hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element (CRE)-binding protein binding to …
AT Pearman, WY Chou, KD Bergman… - Journal of Biological …, 1996 - ASBMB
Many parathyroid hormone (PTH)-mediated events in osteoblasts are thought to require
immediate early gene expression. PTH induces the immediate early gene, c-fos, in this cell
type through a cAMP-dependent pathway. The present work investigated the nuclear
mechanisms involved in PTH regulation of c-fos in the osteoblastic cell line, UMR 106-01. By
transiently transfecting c-fos promoter 5′ deletion constructs into UMR cells, we
demonstrated that PTH induction of the c-fos promoter requires the major cAMP response …
immediate early gene expression. PTH induces the immediate early gene, c-fos, in this cell
type through a cAMP-dependent pathway. The present work investigated the nuclear
mechanisms involved in PTH regulation of c-fos in the osteoblastic cell line, UMR 106-01. By
transiently transfecting c-fos promoter 5′ deletion constructs into UMR cells, we
demonstrated that PTH induction of the c-fos promoter requires the major cAMP response …