[HTML][HTML] Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
RW Schrier, W Wang, B Poole… - The Journal of clinical …, 2004 - Am Soc Clin Investig
RW Schrier, W Wang, B Poole, A Mitra
The Journal of clinical investigation, 2004•Am Soc Clin InvestigAcute renal failure (ARF), characterized by sudden loss of the ability of the kidneys to
excrete wastes, concentrate urine, conserve electrolytes, and maintain fluid balance, is a
frequent clinical problem, particularly in the intensive care unit, where it is associated with a
mortality of between 50% and 80%. In this review, the epidemiology and pathophysiology of
ARF are discussed, including the vascular, tubular, and inflammatory perturbations. The
clinical evaluation of ARF and implications for potential future therapies to decrease the high …
excrete wastes, concentrate urine, conserve electrolytes, and maintain fluid balance, is a
frequent clinical problem, particularly in the intensive care unit, where it is associated with a
mortality of between 50% and 80%. In this review, the epidemiology and pathophysiology of
ARF are discussed, including the vascular, tubular, and inflammatory perturbations. The
clinical evaluation of ARF and implications for potential future therapies to decrease the high …
Acute renal failure (ARF), characterized by sudden loss of the ability of the kidneys to excrete wastes, concentrate urine, conserve electrolytes, and maintain fluid balance, is a frequent clinical problem, particularly in the intensive care unit, where it is associated with a mortality of between 50% and 80%. In this review, the epidemiology and pathophysiology of ARF are discussed, including the vascular, tubular, and inflammatory perturbations. The clinical evaluation of ARF and implications for potential future therapies to decrease the high mortality are described.
The Journal of Clinical Investigation