Laminin receptors
RP Mecham - Annual review of cell biology, 1991 - annualreviews.org
Annual review of cell biology, 1991•annualreviews.org
Laminin is a large, multichain glycoprotein that provides a link between the cell and
structural components of the basement membrane. A typical laminin molecule consists of
three polypeptide chains-A (440 kd), BI (200 kd), and B2 (220 kd)-that are linked via
disulfide bonds to form an asymmetric cross-structure (Figure 1). Each short arm has two or
three small globular domains and there is one large globular domain at the end of the long
arm. The A chain has considerable sequence and structural homology with the smaller B …
structural components of the basement membrane. A typical laminin molecule consists of
three polypeptide chains-A (440 kd), BI (200 kd), and B2 (220 kd)-that are linked via
disulfide bonds to form an asymmetric cross-structure (Figure 1). Each short arm has two or
three small globular domains and there is one large globular domain at the end of the long
arm. The A chain has considerable sequence and structural homology with the smaller B …
Laminin is a large, multichain glycoprotein that provides a link between the cell and structural components of the basement membrane. A typical laminin molecule consists of three polypeptide chains-A (440 kd), BI (200 kd), and B2 (220 kd)-that are linked via disulfide bonds to form an asymmetric cross-structure (Figure 1). Each short arm has two or three small globular domains and there is one large globular domain at the end of the long arm. The A chain has considerable sequence and structural homology with the smaller B chains, but differs in that it has a large globular domain at the C-terminus that represents about 25% of its mass
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