[HTML][HTML] The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans
LJ Heung, C Luberto, A Plowden, YA Hannun… - Journal of Biological …, 2004 - ASBMB
The sphingolipid biosynthetic pathway generates bioactive molecules crucial to the
regulation of mammalian and fungal physiological and pathobiological processes. In
previous studies (Luberto, C., Toffaletti, DL, Wills, EA, Tucker, SC, Casadevall, A., Perfect,
JR, Hannun, YA, and Del Poeta, M.(2001) Genes Dev. 15, 201–212), we demonstrated that
an enzyme of the fungal sphingolipid pathway, Ipc1 (inositol-phosphorylceramide synthase-
1), regulates melanin, a pigment required for the pathogenic fungus Cryptococcus …
regulation of mammalian and fungal physiological and pathobiological processes. In
previous studies (Luberto, C., Toffaletti, DL, Wills, EA, Tucker, SC, Casadevall, A., Perfect,
JR, Hannun, YA, and Del Poeta, M.(2001) Genes Dev. 15, 201–212), we demonstrated that
an enzyme of the fungal sphingolipid pathway, Ipc1 (inositol-phosphorylceramide synthase-
1), regulates melanin, a pigment required for the pathogenic fungus Cryptococcus …