[HTML][HTML] An endoplasmic reticulum stress-specific caspase cascade in apoptosis: cytochrome c-independent activation of caspase-9 by caspase-12

N Morishima, K Nakanishi, H Takenouchi… - Journal of Biological …, 2002 - ASBMB
Activation of caspase-12 from procaspase-12 is specifically induced by insult to the
endoplasmic reticulum (ER)(Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner,
BA, and Yuan, J.(2000) Nature 403, 98–103), yet the functional consequences of caspase-
12 activation have been unclear. We have shown that recombinant caspase-12 specifically
cleaves and activates procaspase-9 in cytosolic extracts. The activated caspase-9 catalyzes
cleavage of procaspase-3, which is inhibitable by a caspase-9-specific inhibitor. Although …