[PDF][PDF] Ryanodine receptors, FKBP12, and heart failure
AR Marks - Front Biosci, 2002 - article.imrpress.com
Front Biosci, 2002•article.imrpress.com
Introduction 3. Ryanodine Receptors: Structure and Function 3.1. RyR2 complex is formed
via leucine/isoleucine zippers 3.2. FKBP12. 6 regulates RyR2 4. PKA Phosphorylation
regulates RyR2 function 4.1. PKA Phosphorylation of RyR2 dissociates FKBP12. 6 from the
channel 4.2. Cellular affects of PKA phosphorylation of RyR2 5. RyR2 mutations linked to
sudden cardiac death 6. Molecular mechanisms underlying β-adrenergic receptor blockade
therapy for heart failure 7. Conclusions and perspective
via leucine/isoleucine zippers 3.2. FKBP12. 6 regulates RyR2 4. PKA Phosphorylation
regulates RyR2 function 4.1. PKA Phosphorylation of RyR2 dissociates FKBP12. 6 from the
channel 4.2. Cellular affects of PKA phosphorylation of RyR2 5. RyR2 mutations linked to
sudden cardiac death 6. Molecular mechanisms underlying β-adrenergic receptor blockade
therapy for heart failure 7. Conclusions and perspective
Abstract
Introduction 3. Ryanodine Receptors: Structure and Function 3.1. RyR2 complex is formed via leucine/isoleucine zippers 3.2. FKBP12. 6 regulates RyR2 4. PKA Phosphorylation regulates RyR2 function 4.1. PKA Phosphorylation of RyR2 dissociates FKBP12. 6 from the channel 4.2. Cellular affects of PKA phosphorylation of RyR2 5. RyR2 mutations linked to sudden cardiac death 6. Molecular mechanisms underlying β-adrenergic receptor blockade therapy for heart failure 7. Conclusions and perspective
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