[HTML][HTML] Glycogen synthase kinase-3β regulates growth, calcium homeostasis, and diastolic function in the heart
A Michael, S Haq, X Chen, E Hsich, L Cui… - Journal of Biological …, 2004 - ASBMB
Glycogen synthase kinase (GSK) 3β is a negative regulator of stress-induced cardiomyocyte
hypertrophy. It is not clear, however, if GSK-3β plays any role in regulating normal cardiac
growth and cardiac function. Herein we report that a transgenic mouse expressing wild type
GSK-3β in the heart has a dramatic impairment of normal post-natal cardiomyocyte growth
as well as markedly abnormal cardiac contractile function. The most striking phenotype,
however, is grossly impaired diastolic relaxation, which leads to increased filling pressures …
hypertrophy. It is not clear, however, if GSK-3β plays any role in regulating normal cardiac
growth and cardiac function. Herein we report that a transgenic mouse expressing wild type
GSK-3β in the heart has a dramatic impairment of normal post-natal cardiomyocyte growth
as well as markedly abnormal cardiac contractile function. The most striking phenotype,
however, is grossly impaired diastolic relaxation, which leads to increased filling pressures …