[HTML][HTML] ε Protein kinase C in pathological myocardial hypertrophy: analysis by combined transgenic expression of translocation modifiers and Gαq

G Wu, T Toyokawa, H Hahn, GW Dorn - Journal of Biological Chemistry, 2000 - ASBMB
The ε isoform of protein kinase C (PKC) has a critical cardiotrophic function in normal
postnatal developing heart as demonstrated by cardiac-specific transgenic expression of
εPKC-selective translocation inhibitor (εV1) and activator (ψεRACK) peptides (Mochly-
Rosen, D., Wu, G., Hahn, H., Osinska, H., Liron, T., Lorenz, JN, Robbins, J., and Dorn, GW, II
(2000) Circ. Res. 86, 1173–1179). To define the role of εPKC signaling in pathological
myocardial hypertrophy, εV1 or ψεRACK were co-expressed in mouse hearts with Gα q, a …