Hemodynamic effects of inducible nitric oxide synthase and nitrotyrosine generation in heart failure
M Vanderheyden, J Bartunek, M Knaapen… - The Journal of heart and …, 2004 - Elsevier
OBJECTIVES: The hemodynamic effects of cardiac inducible nitric oxide synthase (iNOS)
and of iNOS-mediated peroxynitrite in patients with left ventricular (LV) dysfunction are
unclear. The present study investigates the incidence and functional significance of iNOS
expression and nitrotyrosine formation in patients with heart failure. METHODS: LV
endomyocardial biopsies obtained from 24 patients with heart failure due to idiopathic
dilated cardiomyopathy (ejection fraction [EF]< 45% and left ventricular end-diastolic volume …
and of iNOS-mediated peroxynitrite in patients with left ventricular (LV) dysfunction are
unclear. The present study investigates the incidence and functional significance of iNOS
expression and nitrotyrosine formation in patients with heart failure. METHODS: LV
endomyocardial biopsies obtained from 24 patients with heart failure due to idiopathic
dilated cardiomyopathy (ejection fraction [EF]< 45% and left ventricular end-diastolic volume …