Cardiac toxicity of singlet oxygen: implication in reperfusion injury
MC Toufektsian, FR Boucher, S Tanguy… - … and Redox Signaling, 2001 - liebertpub.com
MC Toufektsian, FR Boucher, S Tanguy, S Morel, JG De Leiris
Antioxidants and Redox Signaling, 2001•liebertpub.comOxygen-derived free radicals (O2•-, H2O2, and• OH) that are produced during postischemic
reperfusion are currently suspected to be involved in the pathogenesis of tissue injury.
Another reactive oxygen species, the electronically excited molecular oxygen (1O2), is of
increasing interest in the area of experimental research in cardiology. In this review are
discussed the main potential sources of singlet oxygen in the organism, particularly in the
myocardium, the various cardiovascular cytotoxic effects induced by this reactive oxygen …
reperfusion are currently suspected to be involved in the pathogenesis of tissue injury.
Another reactive oxygen species, the electronically excited molecular oxygen (1O2), is of
increasing interest in the area of experimental research in cardiology. In this review are
discussed the main potential sources of singlet oxygen in the organism, particularly in the
myocardium, the various cardiovascular cytotoxic effects induced by this reactive oxygen …
Oxygen-derived free radicals (O2•-, H2O2, and •OH) that are produced during postischemic reperfusion are currently suspected to be involved in the pathogenesis of tissue injury. Another reactive oxygen species, the electronically excited molecular oxygen (1O2), is of increasing interest in the area of experimental research in cardiology. In this review are discussed the main potential sources of singlet oxygen in the organism, particularly in the myocardium, the various cardiovascular cytotoxic effects induced by this reactive oxygen intermediate, and the growing evidence of its involvement in ischemia/reperfusion injury.
Mary Ann Liebert