[HTML][HTML] Reactive oxygen species-and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction
Y Gotoh, JA Cooper - Journal of Biological Chemistry, 1998 - ASBMB
Reactive oxygen species (ROS) have been implicated in the induction of apoptosis by tumor
necrosis factor-α (TNFα) and other cytotoxic insults, although the molecule (s) regulated by
ROS in TNFα signaling have not been identified. Apoptosis signal-regulating kinase 1
(ASK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK)
superfamily that has been shown to be activated during TNFα-induced apoptosis. ASK1
increases apoptosis when overexpressed, but the mechanism of ASK1 activation and the …
necrosis factor-α (TNFα) and other cytotoxic insults, although the molecule (s) regulated by
ROS in TNFα signaling have not been identified. Apoptosis signal-regulating kinase 1
(ASK1) is a member of the mitogen-activated protein kinase kinase kinase (MAPKKK)
superfamily that has been shown to be activated during TNFα-induced apoptosis. ASK1
increases apoptosis when overexpressed, but the mechanism of ASK1 activation and the …