Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational …
TA Buchanan, BE Metzger, N Freinkel… - American journal of …, 1990 - Elsevier
We used the minimal model technique to obtain concurrent measurements of whole-body
insulin sensitivity and pancreatic B-cell responsiveness to glucose during the third trimester
of pregnancy. Insulin sensitivity in normal pregnant women (n= 8) was reduced to only one
third that of a group of nonpregnant women (n= 7). of similar age and relative weight. This
marked insulin resistance was compensated by reciprocal enhancement of the first-and
second-phase insulin responses to intravenous glucose, which were increased threefold as …
insulin sensitivity and pancreatic B-cell responsiveness to glucose during the third trimester
of pregnancy. Insulin sensitivity in normal pregnant women (n= 8) was reduced to only one
third that of a group of nonpregnant women (n= 7). of similar age and relative weight. This
marked insulin resistance was compensated by reciprocal enhancement of the first-and
second-phase insulin responses to intravenous glucose, which were increased threefold as …