[HTML][HTML] Arachidonic acid influences proinflammatory gene induction by stabilizing the inhibitor-κBα/nuclear factor-κB (NF-κB) complex, thus suppressing the nuclear …
KM Stuhlmeier, JJ Kao, FH Bach - Journal of Biological Chemistry, 1997 - ASBMB
Arachidonic acid (AA), through its myriad metabolites, is involved in inflammation in a
number of ways. AA is produced and released by several cell types, including endothelial
cells (EC), and acts on a variety of cells. EC activation plays a key role in inflammation
presumably by modulating the immune response through up-or down-regulation of several
genes. We have previously shown that AA and its nonmetabolizable analogue, 5, 8, 11, 14-
eicosatetraynoic acid (ETYA), inhibit up-regulation of proinflammatory genes in EC. In the …
number of ways. AA is produced and released by several cell types, including endothelial
cells (EC), and acts on a variety of cells. EC activation plays a key role in inflammation
presumably by modulating the immune response through up-or down-regulation of several
genes. We have previously shown that AA and its nonmetabolizable analogue, 5, 8, 11, 14-
eicosatetraynoic acid (ETYA), inhibit up-regulation of proinflammatory genes in EC. In the …