Immunopathologic responses to urinary Tamm-Horsfall protein in the development of
chronic pyelonephritis were examined by four different approaches. First, in a rabbit model,
tubulointerstitial nephritis developed in 64 of 102 rabbits injected intravenously with urine or
rabbit Tamm-Horsfall protein as compared with only one of 17 rabbits in two control groups.
Circulating cytotoxic lymphocytes plus immunoglobulin G (IgG) antibodies against Tamm-
Horsfall protein were found in 51 percent of challenged (urine or Tamm-Horsfall protein) …