[HTML][HTML] Impact of engagement of FcϵRI and CC chemokine receptor 1 on mast cell activation and motility
M Toda, M Dawson, T Nakamura, PMG Munro… - Journal of Biological …, 2004 - ASBMB
CC chemokines participate in the recruitment and activation of immune cells through CC
chemokine receptors (CCRs). Here, we report that cross-talk between CCR1-mediated
signaling pathway and FcϵRI-mediated signaling pathway affects degranulation positively
but affects chemotaxis of mast cells adversely. Costimulation via FcϵRI engagement with
IgE/antigen and CCR1 engagement with recombinant human CCL3 synergistically
enhanced degranulation in rat basophilic leukemia-2H3 cells expressing human CCR1 …
chemokine receptors (CCRs). Here, we report that cross-talk between CCR1-mediated
signaling pathway and FcϵRI-mediated signaling pathway affects degranulation positively
but affects chemotaxis of mast cells adversely. Costimulation via FcϵRI engagement with
IgE/antigen and CCR1 engagement with recombinant human CCL3 synergistically
enhanced degranulation in rat basophilic leukemia-2H3 cells expressing human CCR1 …