[CITATION][C] Differential regulation of signaling pathways for insulin and insulin-like growth factor I.
W Lopaczynski - Acta Biochimica Polonica, 1999 - ojs.ptbioch.edu.pl
The insulin receptor (IR) and the insulin-like growth factor receptor I (IGF-IR) have different
functions in cell growth, apoptosis, differentation, and transformation. Although some of
these differences may be explained by the relative level of receptor expression and receptor
structure (alpha and beta subunits), they may also be attributed to differences in intracellular
signals generated by insulin and IGF-I. The presence of hybrid receptors (IR alphabeta
subunits and IGF-IR alphabeta subunits) making up the heterotetramers has added a new …
functions in cell growth, apoptosis, differentation, and transformation. Although some of
these differences may be explained by the relative level of receptor expression and receptor
structure (alpha and beta subunits), they may also be attributed to differences in intracellular
signals generated by insulin and IGF-I. The presence of hybrid receptors (IR alphabeta
subunits and IGF-IR alphabeta subunits) making up the heterotetramers has added a new …