Growth enhancement of transgenic mice expressing human insulin-like growth factor I

LS Mathews, RE Hammer, RR Behringer… - …, 1988 - academic.oup.com
LS Mathews, RE Hammer, RR Behringer, AJ D'ERCOLE, GI Bell, RL Brinster, RD Palmiter
Endocrinology, 1988academic.oup.com
A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth
factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was
generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line
overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the
normal value. This results in a growth response manifested by a 1.3-fold increase in weight
as a result of selective organomegaly without an apparent increase in skeletal growth. In …
A line of transgenic mice carrying a chimeric gene composed of human insulin-like growth factor I (IGF-I) coding sequences fused to the mouse metallothionein I promoter was generated to study the effects of chronically elevated exposure to IGF-I. Mice in this line overexpress IGF-I in most tissues studied and have circulating IGF-I levels 1.5 times the normal value. This results in a growth response manifested by a 1.3-fold increase in weight as a result of selective organomegaly without an apparent increase in skeletal growth. In addition, expression of the endogenous GH and IGF-I genes is inhibited. These results are consistent with IGF-I playing an important role in the control of somatic growth. (Endocrinology123: 2827–2833, 1988)
Oxford University Press