[HTML][HTML] Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a
S Torii, T Takeuchi, S Nagamatsu, T Izumi - Journal of Biological Chemistry, 2004 - ASBMB
Secretory vesicle exocytosis is a highly regulated process involving vesicle targeting,
priming, and membrane fusion. Rabs and SNAREs play a central role in executing these
processes. We have shown recently that Rab27a and its effector, granuphilin, are involved
in the exocytosis of insulin-containing secretory granules through a direct interaction with the
plasma membrane syntaxin 1a in pancreatic beta cells. Here, we demonstrate that
fluorescence-labeled insulin granules are peripherally accumulated in cells overexpressing …
priming, and membrane fusion. Rabs and SNAREs play a central role in executing these
processes. We have shown recently that Rab27a and its effector, granuphilin, are involved
in the exocytosis of insulin-containing secretory granules through a direct interaction with the
plasma membrane syntaxin 1a in pancreatic beta cells. Here, we demonstrate that
fluorescence-labeled insulin granules are peripherally accumulated in cells overexpressing …
