Far from being the boring, inactive, inert lymphocyte that haematologists of old perceived it
to be, the chronic lymphocytic leukaemia (CLL) cell has set us many complex problems. The
cell is apparently stuck in G0 in cell cycle, yet expresses many activation markers. The cells
apparently manufacture many cytokines and respond in vitro to even more, yet cells entering
even G1 are few. The cell surface marker profile is unique. There is apparently no normal
equivalent of the CLL cell. In part, this may be because the cell is malignant; malignant cells …