Receptor-mediated signal transduction pathways of cells involved in allergy and
inflammations are extremely significant. Lyn is a member of the Src family of non-receptor
protein tyrosine kinases and is associated with a number of cell surface receptors, including
the B-cell antigen receptor and immunoglobulin E receptor (FcεRI). Lyn is necessary for
FcεRI-mediated mast cell activation. To investigate how the level of Lyn is maintained in
mast cell activation, it was studied whether Lyn binds to ubiquitin and is ubiquitinated for …