Initiation and processing of signals from the B cell antigen receptor
M Reth, J Wienands - Annual review of immunology, 1997 - annualreviews.org
M Reth, J Wienands
Annual review of immunology, 1997•annualreviews.orgCurrent models of signal transduction from the antigen receptors on B and T cells still
resemble equations with several unknown elements. Data from recent knock-out
experiments in cell lines and mice contradict the assumption that Src-family kinase and
tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from
these receptors in motion. Using a functional definition of signaling elements, we discuss the
current knowledge of signaling events from the BCR and suggest the existence of an as-yet …
resemble equations with several unknown elements. Data from recent knock-out
experiments in cell lines and mice contradict the assumption that Src-family kinase and
tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from
these receptors in motion. Using a functional definition of signaling elements, we discuss the
current knowledge of signaling events from the BCR and suggest the existence of an as-yet …
Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knock-out experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.
Annual Reviews