[HTML][HTML] Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death
CD Bingle, RW Craig, BM Swales, V Singleton… - Journal of Biological …, 2000 - ASBMB
Mcl-1 is a member of the Bcl-2 family that is regulated transcriptionally and post-
transcriptionally, with expression of the full-length Mcl-1-encoded gene product resulting in
enhanced cell survival. As reported here, the human Mcl-1 gene can also undergo
differential splicing, which yields an internally deleted, death-inducing gene product, Mcl-1
s/Δ TM. Whereas full-length Mcl-1 derives from three coding exons (instead of the two
present in Bcl-2 and other anti-apoptotic members of this family), the Mcl-1 s/Δ TM splice …
transcriptionally, with expression of the full-length Mcl-1-encoded gene product resulting in
enhanced cell survival. As reported here, the human Mcl-1 gene can also undergo
differential splicing, which yields an internally deleted, death-inducing gene product, Mcl-1
s/Δ TM. Whereas full-length Mcl-1 derives from three coding exons (instead of the two
present in Bcl-2 and other anti-apoptotic members of this family), the Mcl-1 s/Δ TM splice …