Spatial discontinuities in human immunodeficiency virus type 1 quasispecies derived from epidermal Langerhans cells of a patient with AIDS and evidence for double …

M Sala, G Zambruno, JP Vartanian, A Marconi… - Journal of …, 1994 - Am Soc Microbiol
M Sala, G Zambruno, JP Vartanian, A Marconi, U Bertazzoni, S Wain-Hobson
Journal of virology, 1994Am Soc Microbiol
A nonhomogeneous spatial distribution of human immunodeficiency virus type 1
quasispecies was observed for epidermal Langerhans cells purified from skin patches taken
from a patient with AIDS soon after death. Each patch presented a unique collection of
sequences, distinct from those of juxtaposed patches or those derived from the other leg.
Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this
partition. The analysis revealed the presence of two distinct cocirculating viral strains …
A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.
American Society for Microbiology