[CITATION][C] Infection of human tonsil histocultures: a model for HIV pathogenesis
S Glushakova, B Baibakov, LB Margolis, J Zimmerberg - 1995 - nature.com
S Glushakova, B Baibakov, LB Margolis, J Zimmerberg
1995•nature.comThe critical events in the progression of AIDS occur in human lymphoid tissue". It is within
tissues that the entire system of cell–cell interactions mediating immune function
progressively deteriorates and ultimately collapses". Primary cul-tures and cocultures of
isolated cells cannot mimic the full cellular repertoire within lymph tissue, nor their functional
relationship to lymphoid tissue structure. Animal models do not fully mimic the characteristic
tissue pathology of human HIV infection “. For this reason, we have developed a tissue …
tissues that the entire system of cell–cell interactions mediating immune function
progressively deteriorates and ultimately collapses". Primary cul-tures and cocultures of
isolated cells cannot mimic the full cellular repertoire within lymph tissue, nor their functional
relationship to lymphoid tissue structure. Animal models do not fully mimic the characteristic
tissue pathology of human HIV infection “. For this reason, we have developed a tissue …
The critical events in the progression of AIDS occur in human lymphoid tissue". It is within tissues that the entire system of cell–cell interactions mediating immune function progressively deteriorates and ultimately collapses". Primary cul-tures and cocultures of isolated cells cannot mimic the full cellular repertoire within lymph tissue, nor their functional relationship to lymphoid tissue structure. Animal models do not fully mimic the characteristic tissue pathology of human HIV infection “. For this reason, we have developed a tissue culture method that retains the complex threedimensional (3-D) spatial cellular organization found in normal human lymphoid tissue. This technology is simple, easily maintained, able to support infection with HIV-1 isolates Of different (l
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