[PDF][PDF] IL-6 trans-signaling: the heat is on

S Rose-John, MF Neurath - Immunity, 2004 - cell.com
S Rose-John, MF Neurath
Immunity, 2004cell.com
The molecular consequence of the fever response has been illuminated by a recent study
showing that a temperature shift to 40° C resulted in increased leukocyte adhesion to tissue
sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin
activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-
6R.
Abstract
The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40°C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.
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