Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
FM Brennan, A Jackson, D Chantry, R Maini… - The Lancet, 1989 - Elsevier
FM Brennan, A Jackson, D Chantry, R Maini, M Feldmann
The Lancet, 1989•ElsevierThe effect of tumour necrosis factor (TNFα) antibodies on synovial cell interleukin-1 (IL-1)
production was investigated in 7 patients with rheumatoid arthritis and in 7 with
osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNFα antibody
in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have
this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1
production was low, despite high concentrations of TNFα, and IL-1 production was not …
production was investigated in 7 patients with rheumatoid arthritis and in 7 with
osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNFα antibody
in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have
this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1
production was low, despite high concentrations of TNFα, and IL-1 production was not …
Abstract
The effect of tumour necrosis factor (TNFα) antibodies on synovial cell interleukin-1 (IL-1) production was investigated in 7 patients with rheumatoid arthritis and in 7 with osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNFα antibody in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1 production was low, despite high concentrations of TNFα, and IL-1 production was not inhibited by anti-TNFα antibody. In rheumatoid arthritis, TNFα may be the main inducer of IL-1, and anti-TNFα agents may be useful in treatment.
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