[HTML][HTML] Activation of an unfolded protein response during differentiation of antibody-secreting B cells
JN Gass, NM Gifford, JW Brewer - Journal of Biological Chemistry, 2002 - ASBMB
The unfolded proteinresponse pathway (UPR) is believed to detect and compensate for
excessive protein accumulation in the endoplasmic reticulum (ER). The UPR can be
induced by pharmacological agents that perturb ER functions, but may also occur during
cellular developmental processes such as the transition of B-lymphocytes into antibody-
secreting plasma cells. Here we show that major UPR components are activated in B cells
stimulated to secrete antibody. Increased expression of UPR targets including the ER …
excessive protein accumulation in the endoplasmic reticulum (ER). The UPR can be
induced by pharmacological agents that perturb ER functions, but may also occur during
cellular developmental processes such as the transition of B-lymphocytes into antibody-
secreting plasma cells. Here we show that major UPR components are activated in B cells
stimulated to secrete antibody. Increased expression of UPR targets including the ER …