Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
L Chen, P Hamrah, C Cursiefen, Q Zhang, B Pytowski… - Nature medicine, 2004 - nature.com
Nature medicine, 2004•nature.com
There are no studies so far linking molecular regulation of lymphangiogenesis and induction
of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor
receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting
(dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity
and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a
mechanism for modulating adaptive immunity in the periphery.
of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor
receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting
(dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity
and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a
mechanism for modulating adaptive immunity in the periphery.
Abstract
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
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