Integrin tyrosine phosphorylation in platelet signaling
DR Phillips, KSS Prasad, J Manganello, M Bao… - Current opinion in cell …, 2001 - Elsevier
DR Phillips, KSS Prasad, J Manganello, M Bao, L Nannizzi-Alaimo
Current opinion in cell biology, 2001•ElsevierThe β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated
during platelet aggregation, causing Shc and myosin to interact with the β-integrin
cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective
aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a
key mediator of β3-integrin signals.
during platelet aggregation, causing Shc and myosin to interact with the β-integrin
cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective
aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a
key mediator of β3-integrin signals.
The β3 integrin cytoplasmic tyrosine (ICY) motif of αIIbβ3 becomes tyrosine phosphorylated during platelet aggregation, causing Shc and myosin to interact with the β-integrin cytoplasmic domain. Platelets from mice lacking β3 ICY motif tyrosines formed defective aggregates and poorly retracted clots, establishing integrin tyrosine phosphorylation as a key mediator of β3-integrin signals.
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