[HTML][HTML] Gas6 anti-apoptotic signaling requires NF-κB activation
F Demarchi, R Verardo, B Varnum, C Brancolini… - Journal of Biological …, 2001 - ASBMB
The growth arrest-specific 6 gene product Gas6 is a growth and survival factor related to
protein S. Gas6 is the ligand of Axl receptor tyrosine kinase; upon binding to its receptor
Gas6 activates the phosphatidylinositol 3-OH kinase (PI3K) and its downstream targets S6K
and Akt. Gas6 anti-apoptotic signaling was previously shown to require functional PI3K and
Akt and to involve Bad phosphorylation in serum-starved NIH 3T3 cells. Here we
demonstrate that Gas6 induces a rapid and transient increase in nuclear NF-κB binding …
protein S. Gas6 is the ligand of Axl receptor tyrosine kinase; upon binding to its receptor
Gas6 activates the phosphatidylinositol 3-OH kinase (PI3K) and its downstream targets S6K
and Akt. Gas6 anti-apoptotic signaling was previously shown to require functional PI3K and
Akt and to involve Bad phosphorylation in serum-starved NIH 3T3 cells. Here we
demonstrate that Gas6 induces a rapid and transient increase in nuclear NF-κB binding …