[HTML][HTML] The role of long-chain fatty acyl-CoA esters in β-cell signal transduction
BE Corkey, JT Deeney, GC Yaney, K Tornheim… - The Journal of …, 2000 - Elsevier
Glucose-induced insulin secretion is associated with inhibition of free fatty acid (FFA)
oxidation, increased esterification and complex lipid formation by pancreatic β-cells.
Abundant evidence favors a role for cytosolic long-chain acyl-CoA (LC-CoA), including the
rapid rise in malonyl CoA, the inhibitory effect of hydroxycitrate or acetyl CoA carboxylase
knockout, both of which prevent malonyl CoA formation, and the stimulatory effect of
exogenous FFA. On the other hand, some evidence opposes the concept, including the fall …
oxidation, increased esterification and complex lipid formation by pancreatic β-cells.
Abundant evidence favors a role for cytosolic long-chain acyl-CoA (LC-CoA), including the
rapid rise in malonyl CoA, the inhibitory effect of hydroxycitrate or acetyl CoA carboxylase
knockout, both of which prevent malonyl CoA formation, and the stimulatory effect of
exogenous FFA. On the other hand, some evidence opposes the concept, including the fall …