Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease
HA Järveläinen, A Orpana, M Perola, VT Savolainen… - Hepatology, 2001 - Elsevier
Twin concordance studies indicate that genetic factors influence the individual susceptibility
for alcoholic liver disease (ALD). Both clinical and experimental data suggest that Kupffer
cell activation by gut-derived endotoxins and other bacterial products is an important
pathogenic factor. Activated Kupffer cells release proinflammatory cytokines, a process that
is regulated by the CD14 endotoxin receptor (CD14). Recently, a C→ T (− 159)
polymorphism in the promoter region of the CD14 gene was detected and found to confer …
for alcoholic liver disease (ALD). Both clinical and experimental data suggest that Kupffer
cell activation by gut-derived endotoxins and other bacterial products is an important
pathogenic factor. Activated Kupffer cells release proinflammatory cytokines, a process that
is regulated by the CD14 endotoxin receptor (CD14). Recently, a C→ T (− 159)
polymorphism in the promoter region of the CD14 gene was detected and found to confer …