[HTML][HTML] Association of immature hypophosphorylated protein kinase Cε with an anchoring protein CG-NAP
M Takahashi, H Mukai, K Oishi, T Isagawa… - Journal of Biological …, 2000 - ASBMB
Protein kinase C (PKC) family requires phosphorylation of itself to become competent for
responding to second messengers. Much attention has been focused on elucidating the role
of phosphorylation in PKC activity; however, it remains unknown where this modification
takes place in the cells. This study examines whether anchoring protein is involved in the
regulation of PKC phosphorylation. A certain population of PKCε in rat brain extracts as well
as that expressed in COS7 cells was associated with an endogenous anchoring protein CG …
responding to second messengers. Much attention has been focused on elucidating the role
of phosphorylation in PKC activity; however, it remains unknown where this modification
takes place in the cells. This study examines whether anchoring protein is involved in the
regulation of PKC phosphorylation. A certain population of PKCε in rat brain extracts as well
as that expressed in COS7 cells was associated with an endogenous anchoring protein CG …