Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid

N Van Rooijen, A Sanders - Hepatology, 1996 - journals.lww.com
Macrophages such as Kupffer cells in the liver are multifunctional cells. They are involved in
host defense mechanisms and have a regulatory role in many biomedical processes. Their
selective depletion, using liposome-encapsulated drugs, forms a widely accepted approach
to studying their functional aspects in vivo. We have compared the Kupffer cell-depleting
activities of liposome-encapsulated clodronate, propamidine, and
ethylenediaminetetraacetic acid (EDTA) for this purpose. These molecules represent the …