[HTML][HTML] Functional, persistent, and extended liver to pancreas transdifferentiation
I Ber, K Shternhall, S Perl, Z Ohanuna… - Journal of Biological …, 2003 - ASBMB
Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development
during embryogenesis, whereas in the adult it controls β-cell function. Here we analyze
whether PDX-1 functions as a pancreatic differentiation factor and a bona fide master
regulator when ectopically expressed in mature fully differentiated liver in vivo. By ectopic
and transient PDX-1 expression in liver in vivo, using the first generation recombinant
adenoviruses, we demonstrate that PDX-1 induces in liver a wide repertoire of both exocrine …
during embryogenesis, whereas in the adult it controls β-cell function. Here we analyze
whether PDX-1 functions as a pancreatic differentiation factor and a bona fide master
regulator when ectopically expressed in mature fully differentiated liver in vivo. By ectopic
and transient PDX-1 expression in liver in vivo, using the first generation recombinant
adenoviruses, we demonstrate that PDX-1 induces in liver a wide repertoire of both exocrine …