Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.

M Arnush, D Gu, C Baugh, SP Sawyer… - … ; a journal of technical …, 1996 - europepmc.org
M Arnush, D Gu, C Baugh, SP Sawyer, B Mroczkowski, T Krahl, N Sarvetnick
Laboratory investigation; a journal of technical methods and pathology, 1996europepmc.org
We examined the distribution of several relevant growth factors in gamma-interferon
transgenic mice, which undergo continual growth and differentiation in the pancreas. As a
result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as
potentially important in mediating some of these regenerative changes. Transient up-
regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing
differentiation into duct-like structures. These ducts have been shown to proliferate and …
We examined the distribution of several relevant growth factors in gamma-interferon transgenic mice, which undergo continual growth and differentiation in the pancreas. As a result, epidermal growth factor (EGF), TGF-alpha, and the EGF receptor were identified as potentially important in mediating some of these regenerative changes. Transient up-regulation of EGF, TGF-alpha, and the EGF receptor were observed in acini undergoing differentiation into duct-like structures. These ducts have been shown to proliferate and potentiate regeneration of the pancreatic islet mass.
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