Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population
IJ Fidler, ML Kripke - Nature genetics, 2003 - nature.com
IJ Fidler, ML Kripke
Nature genetics, 2003•nature.comMore recently, a small set of 17 genes was reported to predict metastatic potential for a
variety of solid tumors2. These findings suggest that most primary tumor cells express a
'metastasis signature', in contrast to the classic model, which predicts that only a rare
subpopulation of primary tumor cells have accumulated the numerous alterations required
for metastasis. Based on this evidence, Bernards and Weinberg3 recently posited that
combinations of early oncogenic alterations, not specific events that promote metastasis …
variety of solid tumors2. These findings suggest that most primary tumor cells express a
'metastasis signature', in contrast to the classic model, which predicts that only a rare
subpopulation of primary tumor cells have accumulated the numerous alterations required
for metastasis. Based on this evidence, Bernards and Weinberg3 recently posited that
combinations of early oncogenic alterations, not specific events that promote metastasis …
More recently, a small set of 17 genes was reported to predict metastatic potential for a variety of solid tumors2. These findings suggest that most primary tumor cells express a ‘metastasis signature’, in contrast to the classic model, which predicts that only a rare subpopulation of primary tumor cells have accumulated the numerous alterations required for metastasis. Based on this evidence, Bernards and Weinberg3 recently posited that combinations of early oncogenic alterations, not specific events that promote metastasis, determine metastatic potential. This hypothesis might explain why metastasis occurs in some individuals with small, localized tumors (that is, tumors whose
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